Christina Ledbetter, PhD

Clinical Neuroscientist

Dr. Ledbetter is a clinical neuroscientist and researcher with a PhD in pharmacology, toxicology, and neuroscience. She specializes in functional Magnetic Resonance Imaging (fMRI) and brain mapping for surgical planning. 

In addition to her work with LearningRx, Dr. Ledbetter is a research fellow in the Department of Neurosurgery at LSU Health Sciences Center in Shreveport, Louisiana, where she is the Director of the Clinical Neuroimaging Lab. Her research expertise is applied to neurological conditions including cognitive impairment, Parkinson’s disease, epilepsy, brain tumors, and traumatic brain injury. Dr. Ledbetter is also President of the Gibson Institute for Cognitive Research.

With a background in both medical imaging and neuroscience, she is an expert at using fMRI to assess changes in the brain following neuroplasticity-based interventions with a particular interest in the Default Mode Network (DMN) and the correlation of changes in network connectivity with changes on neuropsychological testing measures.

Watch Dr. Christina Ledbetter explain how brain training works:

Professional Associations

• Society for Neuroscience
• Organization for Human Brain Mapping

Professional Organizations

• International Neuropsychological Society

Research & Publications

• Objective Neuroradiology: cortical reconstruction and DTI reconstruction, research assistant
• LearningRx brain training improved IQ by 21 points, results of a clinical study
• Beyond Attention: Cognitive Profiles in ADHD, researcher with Gibson Institute
• “A Study of Cognitive Skills & the Brain”, author
• “Mental Sweat” published on Modern Brain Journal
• Published several research articles with Gibson Institute of Cognitive Research

Peer-Reviewed Articles

• Plasma Hydrogen Sulfide: A Biomarker of Alzheimer’s Disease and Related Dementias. Alzheimer’s & Dementia. 17. 10.1002/alz.12305. doi:10.1002/alz.12305
• Remote vs. In-Person Delivery of LearningRx One-on-One Cognitive Training During the COVID-19 Pandemic: A Non-inferiority Study. Frontiers in Psychology, 12, 749898. doi:10.3389/fpsyg.2021.749898 
• Reliability Evidence for the Gibson Assessment of Cognitive Skills (GACS): A Brief Tool for Screening Cognitive Skills Across the Lifespan. Psychology Research and Behavior Management, 14, 31-40. doi:10.2147/PRBM.S291574 
• Sex Specific Cognitive Differences in Parkinson Disease. NPJ Parkinson’s Disease. 6. doi:10.1038/s41531-020-0109-1
• Neuroimaging and Neuropsychological Outcomes Following Clinician-Delivered Cognitive Training for Six Patients with Mild Brain Injury: A Multiple Case Study. Frontiers in Human Neuroscience, 14(229), 1-15. doi.org/10.3389/fnhum.2020.00229
• Ethical Considerations and Lessons Learned in a Randomized Controlled Trial of ThinkRx Cognitive Training for Children with Learning Disabilities and/or ADHD. SAGE Research Methods Cases. doi:10.4135/9781529734072
• Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients Over Age 55: A Multiple Case Study Report. OBM Integrative and Complementary Medicine, 4(3). doi: 10.21926/obm.icm.1903054
• The Promise of Clinician-Delivered Cognitive Training for Children Diagnosed with ADHD. Journal of Mental Health and Clinical Psychology, 3(3), 3-8. doi: 10.29245/2578-2959/2019/3.1180
• ThinkRx Cognitive Training for Adults over Age 50: Clinician-Caregiver Partners in Delivery as Effective as Clinician-Only Delivery. Psychology and Neuroscience, 12(2), 291-306. doi: 10.1037/pne0000162
• Comparing Two Methods of Delivering ThinkRx Cognitive Training to Children Ages 8-14: A Randomized Controlled Trial of Equivalency. Journal of Cognitive Enhancement, 3(3), 261-270. doi.org/10.1007/s41465-018-0094-z
• Clinician-delivered cognitive training for children with attention problems: Effects on cognition and behavior from the ThinkRx randomized controlled trial. Neuropsychiatric Disease and Treatment, 14, 1671-1683. doi: 10.2147/NDT.S165418
• Neuroimaging outcomes of a cognitive rehabilitation training program. Journal of Neuroimaging, 28(2), 225-233. doi: 10.1111/jon.12507
• Cognitive effects of ThinkRx cognitive rehabilitation training for eleven soldiers with brain injury: A retrospective chart review. Frontiers in Psychology, 8(825). doi: 10.3389/fpsyg.2017.00825
• LearningRx cognitive training effects in children ages 8-14: A randomized controlled study. Applied Cognitive Psychology, 30(5), 815-826. doi: 10.1002/acp.3257

Other Profiles & Listings

• Research Gate Profile
• Loop Profile
• Louisiana State University Alumni Listing
• The Epilepsy and Brain Connectivity Laboratory Contributor
• Louisiana Tech University Center Listing